Promoter Methylation Status and Protein Expression of BRCA۲ in Patients with Epithelial Ovarian Cancer

Background: Ovarian cancer is the leading cause of death among gynecological cancers. Changes in the methylation of BRCA۱ and BRCA۲ may be an effective mechanism for breast and ovarian cancer. This study evaluates the protein expression and methylation status of BRCA۲ in Iranian patients.Methods: We assessed ۶۰ Mullerian-type ovarian cancers by methylation-specific PCR assays and immunohistochemistry.Results: According to methylation status analysis, there were ۷ of ۶۰ (۱۱.۶۶%) methylated cases that had low protein expression.Conclusion: We concluded that changes in the methylation status of BRCA۲ cannot be used as an appropriate biomarker to ascertain the development of ovarian cancer.