Osteopoikilosis: A Sign Mimicking Skeletal Metastases in a Cancer Patient

Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-2-1_007

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Osteopoikilosis is a rare benign osteosclerotic bone disorder that may be misdiagnosed as skeletal metastases. Here we describe a case of coincidental breast cancer and osteopoikilosis mimicking skeletal metastases. A ۴۱-year-old woman underwent right modified radical mastectomy in April ۲۰۰۷. Twenty-eight months after initial treatment, the patient complained of bilateral knee and foot pain. Plain X-rays of the feet and knees showed multiple well-defined osteosclerotic lesions. According to the radiographic appearance, the most likely differential diagnoses included skeletal metastases from breast cancer and osteopoikilosis. A whole-body bone scintigraphy showed no increase in uptake by the sclerotic lesions, and serum lactic dehydrogenase, carcinoembryon- ic antigen, alkaline phosphatase and cancer antigen ۱۵-۳ were not elevated. We therefore diagnosed the patient’s skeletal lesions as osteopoikilosis. This case and our literature review suggest that the radiographic appearance of osteopoikilosis may mimic or mask skeletal metastases, potentially leading to misdiagnosis in patients with cancer.

Authors

Sepideh Sefidbakht

Department of Radiology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Yaghoub Ashouri-Taziani

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Sareh Hoseini

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansrai

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Ahmadloo

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrolahi

Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Department of Radiology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran