The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7)

Background: Magnetic nanoparticles attract increasing interest due to their use in cancer therapy and as drug carriers for several other diseases. The present study investigates the physiochemical properties of quercetin-conjugated superparamagnetic Fe3O4 nanoparticles and their effects on breast cancer cell line MCF-7. Methods: A simple precipitation method was used to prepare the Poly Ethylene Imine (PEI)-coated Fe3O4 nanoparticles; they were then conjugated with flavonoid-compound quercetin on the surface via carboxylic/amine group using nanoprecipitation method. Then, the physical and chemical parameters were calculated using Zeta-sizer, scanning electron microscopy (SEM), and extract release patterns at 37 and 42 0C. Finally, the toxicity level of this quercetin- conjugated nanosystem on the MCF-7 cells was investigated by MTT assay. Results: The results showed that the prepared nanosystem attained about 74% of quercetin inclusion, 91.2 nm size, 65.1 mV zeta potential, spherical morphology and a controlled release. Compared to Fe3O4 nanoparticles and pure quercetin, MTT and microscopy analysis revealed that quercetin-conjugated Fe3O4 nanoparticles induced considerable cytotoxicity, and morphology changes against MCF7 cells. Conclusion: Quercetin-conjugated Fe3O4 nanoparticles have appropriate physiochemical properties; they can be a suitable carrier for drug delivery and a promising therapy for candidates. Corresponding Author:Bibi Fatemeh Haghiralsadat View Orcid in Profile You can search for this author in PubMed     Google Scholar Profile

The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7) Keywords:

Nanoparticles , Quercetin , Fe3O4 , Breast cancer