Antifungal susceptibility profiles of otomycosis etiological agents in Ahvaz, Iran

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نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CUMM-6-2_004

تاریخ نمایه سازی: 11 آذر 1402

Abstract:

Background and Purpose: Otomycosis is a secondary ear fungal infection among predisposed individuals in humid conditions. Aspergillus species are the most common etiologic agents of this infection. Several ototopical antifungals are currently used for the treatment of this disease; however, recurrence and treatment failure are usually observed in some cases. Regarding this, the present study was conducted to investigate the antifungal activity of caspofungin, azoles, and terbinafine against the isolated agents of otomycosis. Materials and Methods: This study was conducted on the specimens collected from ۹۰ patients with otomycosis. The samples were cultured on Sabouraud dextrose agar and identified based on morphological characteristics, physiological tests, and microscopic features. Furthermore, the microdilution method was used for antifungal susceptibility testing according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Finally, the minimum inhibitory concentration (MIC) and minimum effective concentration (MEC) ranges, MIC/MEC۵۰, MIC/MEC۹۰, and geometric mean (GM) MIC/MEC were calculated for the isolates. Results: According to the results, ۷۷ patients with otomycosis were positive for different Aspergillus (۸۸.۳%) and Candida (۱۱.۷%) species. Aspergillus niger complex (n=۳۶) was found to be the most common agent, followed by A. flavus, A. terreus, and A. nidulans complexes. Furthermore, epidemiological cutoff values (ECVs) were lower than those presented by the CLSI for itraconazole and caspofungin in ۹۸.۵% and ۴۲.۶% of Aspergillus species, respectively. Terbinafine exhibited a great activity against Aspergillus species, while fluconazole revealed a low activity against both Aspergillus species. Based on the results, ۷۷.۸% of Candida species were resistant to caspofungin; however, miconazole and econazole had low MIC ranges. Conclusion: Aspergillus niger and A. flavus complexes were identified as the most common agents accounting for ۸۵.۷% of the isolates. In addition, terbinafine was identified as the best antifungal for both Aspergillus and Candida species. Moreover, tested azoles had relatively low MICs, whereas most of the isolates had the MIC values beyond the caspofungin ECVs.

Authors

Maral Gharaghani

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Marzieh Halvaeizadeh

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Gholam Ali Jalaee

Otorhinolaryngologist, Apadana Hospital, Sorosh Street, Ahvaz, Iran

Simin Taghipoor

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Neda Kiasat

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Ali Zarei Mahmoudabadi

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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  • Zarei Mahmoudabadi A, Abshirini H, Rahimi R. Fungal flora of ...
  • Gharaghani M, Seifi Z, Zarei Mahmoudabadi A. Otomycosis in Iran: ...
  • Kazemi A, Majidinia M, Jaafari A, Ayatollahi Mousavi SA, Zarei ...
  • Viswanatha B, Naseeruddin K. Fungal infections of the ear in ...
  • Szigeti G, Sedaghati E, Mahmoudabadi AZ, Naseri A, Kocsube S, ...
  • Abastabar M, Haghani I, Ahangarkani F, Rezai MS, Taghizadeh Armaki ...
  • Barati B, Okhovvat SA, Goljanian A, Omrani MR. Otomycosis in ...
  • Ho T, Vrabec JT, Yoo D, Coker NJ. Otomycosis: clinical ...
  • Vennewald I, Klemm E. Otomycosis: diagnosis and treatment. Clin Dermatol. ...
  • Khan F, Muhammad R, Khan MR, Rehman F, Iqbal J, ...
  • Ologe F, Nwabuisi C. Treatment outcome of otomycosis in Ilorin, ...
  • Maertens J, Raad I, Petrikkos G, Boogaerts M, Selleslag D, ...
  • Mora-Duarte J, Betts R, Rotstein C, Colombo AL, Thompson-Moya L, ...
  • Badali H, Fakhim H, Zarei F, Nabili M, Vaezi A, ...
  • Kahn JN, Hsu MJ, Racine F, Giacobbe R, Motyl M. ...
  • Diekema DJ, Messer SA, Hollis RJ, Jones RN, Pfaller MA. ...
  • Clinical and Laboratory Standards Institute. Reference method for broth dilution ...
  • Clinical and Laboratory Standards Institute. Reference method for broth dilution ...
  • Espinel-Ingroff A, Diekema DJ, Fothergill A, Johnson E, Pelaez T, ...
  • Clinical and Laboratory Standards Institute. Epidemiological cutoff values for antifungal ...
  • Clinical and Laboratory Standards Institute. Reference method for broth dilution ...
  • Munguia R, Daniel SJ. Ototopical antifungals and otomycosis: a review. ...
  • Chappe M, Vrignaud S, de Gentile L, Legrand G, Lagarce ...
  • Jia X, Liang Q, Chi F, Cao W. Otomycosis in ...
  • Nemati S, Hassanzadeh R, Khajeh Jahromi S, Delkhosh Nasrollah Abadi ...
  • Saunders JE, Raju RP, Boone JL, Hales NW, Berryhill WE. ...
  • Karaarslan A, Arikan S, Ozcan M, Ozcan KM. In vitro ...
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  • Pfaller M, Boyken L, Hollis R, Messer S, Tendolkar S, ...
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