Neuroprotective Effects of Quercetin in Alzheimer's Disease

Background: Alzheimer's disease (AD) primarily affects elderly persons and accounts for ۶۰–۸۰% of all dementia cases ۶۵ years of age or older. A flavonoid with remarkable pharmacological effects and positive therapeutic potential, quercetin, is. It is extensively dispersed across plants and is frequently consumed, primarily in fruits and vegetables, in everyday meals.Methods: Studies with data that were recently published were often sourced from search engines like PubMed, Scopus, and Medline and included in this article. Our search criteria were “[Quercetin (Title/Abstract)] AND [Alzheimer’s disease (Title/Abstract) OR Alzheimer disease (Title/Abstract)].”Results: In this review, we give a summary of the most recent research on quercetin's potential as a lead drug in clinical applications and its connection to cognitive function in Alzheimer's disease. In a number of in vitro and in vivo models, it displays advantageous qualities against general processes of AD pathogenesis. By reducing oxidative stress and neuroinflammation, it safeguards neuronal cells. Quercetin has anti-disease Alzheimer's effects that include inhibiting tau phosphorylation and A aggregation. By preventing the AChE enzyme from hydrolyzing acetylcholine, it raises acetylcholine levels. Even though it exhibits neuroprotective efficacy in a number of in vitro and animal models, in vivo investigations have found that it undergoes substantial metabolic processing after entering the body through the gut, which has an impact on its bioavailability.Conclusion: Future clinical studies of quercetin and its analogues as neuroprotective medicines must increase their bioavailability by creating related compounds with better stomach and brain penetration, which will probably improve clinical efficacy

Keywords:

Alzheimer’s disease , clinical directions , mechanistic insights , polyphenols , quercetin