Curcumin as New Option in the Treatment of Alzheimer's Disease

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects that has been shown to be effective in ameliorating cognitive decline in AD patients.Methods: Databases such as Embase, Web of Science, PubMed and The Cochrane Library were searched from the database establishment to December ۲۰۲۲ to collect in vivo, and clinical studies of Curcumin and Curcuma longa Extract in the treatment of AD. Then the literature was screened and the data were extracted.Results: Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyperlipidemia. For prevention and treatment of AD, curcumin has been shown to effectively maintain the normal structure and function of cerebral vessels, mitochondria, and synapses, reduce risk factors for a variety of chronic diseases, and decrease the risk of AD. The effect of curcumin on AD involves multiple signaling pathways: anti-amyloid and metal iron chelating properties, antioxidation and anti-inflammatory activities.Conclusion: Based on the main findings detailed above, curcumin will lead to a promising treatment for AD. The clinically studied chemical properties of curcumin and its various effects on AD shows the possibility to do further research and develop better drugs based on curcumin for treating AD

Keywords:

Curcumin , Neurodegenerative disorders , Alzheimer's Disease.