A quick and easy high performance liquid chromatography method for evaluation of cefixime in human plasma
Publish place: Pharmaceutical and Biomedical Research، Vol: 1، Issue: 4
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
View: 57
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_PBRE-1-4_003
تاریخ نمایه سازی: 10 دی 1402
Abstract:
Cefixime is essential member of orally energetic third generation cephalosporin and has tremendous activity aligned with many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation. A simple and available reversed-phase HPLC method with UV detection has been urbanized and validate for cefixime evaluate in human plasma using a C۱۸ analytical column and a mobile phase of tetrabutylammonium hydroxide (pH ۶.۵)-acetonitrile (۳:۱ v/v). The detection wavelength was ۲۸۰ nm. To method observed major linear response-concentration association all through the cefixime concentration range of ۱۵-۱۰۰ ng/ml, with the average accuracy within-run and between-run values of ۹۷.۲۹% and ۹۹.۲۷%. The average drug recovery from plasma was ۹۸.۲% throughout the linear concentration range. The limits of detection (LOD) and quantitation (LOQ) of the method were ۵ and ۱۵ ng/ml, respectively. The method is quick, easy, very steady and precise for the partition, assignment, evaluation of cefixime in human plasma.
Keywords:
Authors
Hossein Danafar
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :