Anticoagulative Effect of Two Species of Brown Algae; Sargassum Angustifolium and Cystoseira Indica
Publish place: Research in Molecular Medicine، Vol: 8، Issue: 3
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_REMJ-8-3_004
تاریخ نمایه سازی: 20 دی 1402
Abstract:
Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica).
Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on ۱۰ normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT).
Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S.
Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
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Authors
Narges Obeidi
Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Mohammad Javad Mousavi
Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Arghavan Hosseinpouri
Department of Cellular and Molecular Sciences, Faculty of Sciences, Persian Gulf University, Bushehr, Iran.
Hamideh Malekhayati
Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran.
Elham Ehsandoost
Department of Food Science & Technology, Shiraz University, Shiraz, Iran.
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