Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
Publish place: Research in Molecular Medicine، Vol: 3، Issue: 1
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_REMJ-3-1_004
تاریخ نمایه سازی: 22 دی 1402
Abstract:
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitative trait that is controlled by interactions among several quantitative trait loci. Many biological data is presented in the context of biological networks and evaluation of biological networks is considered as the essential key to understanding complex biological systems. In this research, we used combination of information about quantitative trait loci of hypercholesterolemia with information of gene ontology and protein–protein interaction network for identification of genes associated with hypercholesterolemia. For this disease, we introduced ۱۶ new genes which were in quantitative trait loci regions and were associated with the hypercholesterolemia disease in terms of gene ontology characteristics.
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Authors
Ali Kazemipour
Institute of Biochemistry and Biophysics, University of Tehran
Bahram Goliaei
Institute of Biochemistry and Biophysics, University of Tehran
Hamid Pezeshk
University of Tehran
Behjat Kalantari khandani
Kerman University of Medical Sciences
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