Studying Effects of Gold Nanoparticle on Dose Enhancement in Megavoltage Radiation

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JBPE-5-4_004

تاریخ نمایه سازی: 30 دی 1402

Abstract:

Background: Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers.Objective: The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and thereby further understanding of GNP-enhanced radiotherapy. Methods: Effective range, defection angle, dose deposition, energy, and interaction processes of electrons produced from the interaction of x-rays with a GNP were calculated by Monte Carlo simulations. The MCNPX code was used to simulate and track electrons generated from ۳۰ and ۵۰ nm diameter GNP when it is irradiated with a cobalt-۶۰ and ۶MV photon and electron beam in water. Results: When a GNP was present, depending on beam types used, secondary electron production increased by ۱۰- to ۲۰۰۰-fold compared to absence of a GNP. Conclusion: GNPs with larger diameters also contributed to more doses.

Authors

M Khadem Abolfazli

Babol medical university

S R Mahdavi

Iran Medical university

M Mahdavi

Mazandaran university

Gh Ataei

Babol Medical university