Modification of Source Strength in Low-Dose-Rate Lung Brachytherapy with ۱۲۵I and ۱۰۳Pd seeds

Background: A new treatment approach for most patients who have undergone early stage non-small-cell lung carcinoma (NSCLC) is wedge resection plus permanent implant brachytherapy. However, the specification of dose to medium at low energies especially in heterogeneous lung is unclear yet. Objective: The present study aims to modify source strength for different configurations of ۱۲۵I and ۱۰۳Pd seeds used in lung permanent implant brachytherapy.Methods: Different arrays of ۱۲۵I and ۱۰۳Pd seeds were simulated by MCNPX code in protocol-based water vs. actual ۳D lung environments. Absorbed dose was, then, scored in both mediums. Dose differences between both environments were calculated and source strength was modified for the prescription point. In addition, lung-to-water absorbed dose ratio was obtained and presented by precise equations.Results: Due to significant differences in prescription dose, source strength was modified ۱۶%-۱۹% and ۳۷%-۴۳% for different configurations of ۱۲۵I and ۱۰۳Pd seeds, respectively. In addition, depth-dependent dose differences were observed between the actual lung and protocol-based water mediums (dose difference as a function of depth). Conclusion: Modification of source strength is essential for different arrangements of ۱۲۵I and ۱۰۳Pd seeds in lung implantation. Modified source strength and presented equations are recommended to be considered in future studies based on lung brachytherapy.

Keywords:

۱۲۵I seed , ۱۰۳Pd seed , lung permanent implant brachytherapy , Monte Carlo Method