Magnetic Targeting of Magneto-Plasmonic Nanoparticles and Their Effects on Temperature Profile of NIR Laser Irradiated to CT۲۶ Tumor in BALB/C Mice

Background: Photothermal therapy (PTT) is a promising method in the field of cancer hyperthermia. In this method, interaction between laser light and photosensitizer material, such as plasmonic nanoparticles, leads into a localized heating. Recent efforts in the area of PTT aim to exploit targeting strategies for preferential accumulation of plasmonic nanoparticles within the tumor. Objective: To investigate the impact of magneto-plasmonic (Au@Fe۲O۳ ) nanoparticles on temperature profile of CT۲۶ tumor, bearing mice were irradiated by NIR laser.Material and Methods: In this in vivo study, Au@Fe۲O۳  NPs were injected intraperitoneally to Balb/c mice bearing CT۲۶ colorectal tumor. Immediately after injection, a magnet (magnetic field strength of ۰.۴ Tesla) was placed on the tumor site for ۶ hours in order to concentrate nanoparticles inside the tumor. In the next step, the tumors were exposed with NIR laser source (۸۰۸ nm; ۲ W/cm۲; ۵ min). Results: Tumor temperature without magnetic targeting increased ~۷ ± ۰.۹ °C after NIR irradiation, whereas the tumors in magnetic targeted group experienced a temperature rise of ~۱۲ ± ۱.۴ °C. Conclusion: It is concluded that Au@Fe۲O۳ nanoparticle is a good candidate for therapeutic nanostructure in cancer photothermal therapy.

Keywords:

cancer , Nanomedicine , Nanoparticles , Laser Therapy , Hyperthermia