Effect of Swimming Training in Withdrawal Period on Thyroid Hormones of Addicted Rats

Introduction: Today, drug use is increasing in the world. Physiological changes in the body are one of the most important consequences of drug use; one of the most important of these changes is the hormonal changes in the body. Therefore, the purpose of this study was to investigate the effect of swimming training in addiction treatment on thyroid hormones in methadone addicted rats. Methods: Rats were randomly divided into seven groups, including: (۱) eight weeks of swimming training, (۲) eight weeks of methadone consumption, (۳) eight weeks of swimming training with methadone, (۴) four weeks of methadone and four weeks of non-methadone consumption, (۵) four weeks of methadone and four weeks of swimming training, (۶) four weeks of swimming training with methadone and four weeks of swimming without methadone, and (۷) control. The swimming training consisted of three sessions per week and each session was ۳۰ minutes. Also, methadone was injected daily at ۲ mg / kg body weight of methadone peritoneally. Blood samples were collected ۲۴ hours after the last training session. For analysis of data, Kolmogorov-Smirnov test and one way analysis of variance (ANOVA) were used (p≤۰.۰۵). Results: Eeight weeks of swimming training, eight weeks of methadone consumption, eight weeks of swimming training with methadone and also four weeks of swimming training during methadone withdrawal period had no significant effect on thyroxine (p = ۰.۲۹), triiodothyronine p= ۰.۰۶) and thyroid stimulating hormone (p = ۰.۲۴) in rats. Conclusion: Eight weeks of swimming training, methadone consumption, swimming practice along with methadone and also four weeks of swimming training during methadone withdrawal period have no significant effect on thyroid hormones in rats.

Keywords:

Swimming , Methadone , Addiction , Thyroxine , Triiodothyronine , Thyroid Stimulating Hormone