Effect of Six Weeks Light Intensity Interval Training on ANP and BNP Gene Expression Levels after Myocardial Infarction

Introduction: Myocardial infarction (MI) is the irreversible cell death caused by ischemia in parts of myocardium. Atrial and brain natriuretic peptides (ANP and BNP) are known as strong markers of myocardial infarction. This research aimed to evaluate the effect of precedent of six-week light intensity interval training (LIIT) on the ANP and BNP gene expression in rats after Myocardial Infarction. Method: Twelve Wistar male rats of ۱۰ weeks old and mean weight ۲۵۰-۳۰۰gr were allocated in two groups with six Rats in each groups of ۱. LIIT (۶۰ minutes interval running on a treadmill, each cycle including four minutes of running with an intensity of ۵۵-۶۰% VO۲max and two minutes of active recovery with a ۴۵-۵۰% VO۲max intensity, three days a week for six weeks) and ۲. control group (without any precedent of training). Real-time PCR was used to assess the expression of ANP and BNP genes in myocardium (after inducing MI By blocking left coronary artery by surgery). For statistical analysis of data independent sample t test (p≤۰.۰۵) was used. Results: Light intensity interval training has significant effect on decreasing the gene expression of ANP (p=۰.۰۱) and BNP (p=۰.۰۰۱) in rats after myocardial infarction. Conclusion: It appears that adaptation to light intensity interval training controls and moderates the secretion of cardiac hormones in rats after myocardial infarction.

Keywords:

Myocardial Infarction , ANP , BNP , Light Intensity Interval Training