The effect of silymarin on liver injury induced by Thioacetamide in rats

Introduction: In this study the protective effects of Silymarin was investigated against thioacetamide (TAA) induced hepatotoxicity in rat. Methods: In an experimental study ۲۴ male Wistar rats were designated in four equal groups as follows: Control group, the group treated with thioacetamide (TAA), Silymarin (۴۰۰ mg/kg for ۳ weeks) + TAA (۴۰۰ mg/kg), TAA (۴۰۰ mg/kg) + Silymarin (۴۰۰ mg/kg for ۳ weeks). The levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) lactate dehydrogenase (LDH) and total bilirubin were measured to assess the hepatotoxicity and hepatoprotection. Results: TAA significantly increased AST, ALT, ALP, LDH and bilirubin. Treatment by Silymarin caused a significant reduction in serum levels of AST, ALT, ALP, LDH and bilirubin contents. Conclusion: The results indicate a protective effect for Silymarin against thioacetamide induced hepatotoxicity which might be due to its ability to block the bioactivity of thioacetamide.