Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial

Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.Materials and Methods: In this double-blinded randomized clinical trial, ۶۰ patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=۳۰) and control (N=۳۰) groups. Apart from their standard treatment, the intervention group received ۴۰ mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the ۶۰-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV۱). Asthma control test (ACT) was completed every ۳۰ days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.Results: Totally, ۳۱ patients (۵۱.۷%) were male and the mean age was ۵۱.۴۵±۱۲.۵۸ years. FEV۱ was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.

Keywords:

Asthma , Nano-curcumin , Quality of life