Investigating the antibiotic resistance pattern of Escherichia coli isolates causing urinary tract infection in patients referred to Imam Khomeini Hospital in Shirvan city in the year ۲۰۲۲

BACKGROUND AND OBJECTIVESUrinary tract infection is one of the most common bacterial infections around the world, and Escherichia coli is the most common cause of urinary tract infections in the world. Considering the increasing antibiotic resistance and since there is a direct relationship between antimicrobial levels prescribed and the level of resistance seen in a wide range of organisms. Therefore, this study was conducted with the aim of investigating the antibiotic resistance of Escherichia coli at Imam Khomeini Hospital in Shirvan.MATERIALS AND METHODSIn this cross-sectional descriptive study that was conducted from April to March ۲۰۲۲, ۲۰۸۹ urine culture samples were sent from outpatients and inpatients at Imam Khomeini Hospital in Shirvan city, ۱۲۲ samples were positive. Different bacterial culture environments as well as different biochemical tests were used to identify bacterial isolates and disc diffusion method was used to check the antibiotic resistance of Escherichia coli bacteria.RESULTS AND DISCUSSIONOut of ۱۲۲ positive samples in ۱۴۰۱, ۷۷ samples are related to Escherichia coli bacteria, of which ampicillin-sulbactam antibiotic (۶۶.۶۶%) is the most resistant and nitrofurantoin (۳.۲۲%) is the least resistant. Resistance of other antibiotics, respectively, Cefotaxime (۵۸.۹%), Cefixime (۵۷.۱%), Cefazolin (۵۱.۲۱%), Doxycycline (۴۵.۹%), Ceftazidime (۴۵%), Ciprofloxacin (۳۱%) Gentamicin (۹.۲۱%).CONCLUSIONIn general, according to the results, the most resistant antibiotics are ampicillin-sulbactam and vesofotaxime, which are recommended not to be prescribed due to their resistance and ineffectiveness in treatment. Nitrofurantoin and gentamicin are the most sensitive, respectively.

Keywords:

Urinary tract infection , Escherichia coli , antibiotic resistance