The Situation of New Risk Factors of Cardiovascular Disease in Urban Population of Isfahan

During recent years, many epidemiological studies on risk factors of cardiovascular disease (CVD) have been preformed among which are fibrinogen, activity of factor VII, lipoprotein (a), and hemocystein as new CVD risk factors. Through completed studies, it is found that in urban population of Isfahan more than one risk factor (hypertension, smoking, hypercholesterolemia, diabetes and obesity) are seen in ۳۲% of men and ۴۱% of women. However, it is necessary to assess the new CVD risk factors in this population. Accordingly, a descriptive cross-sectional study was performed in ۱۹۹۸-۹۹ and ۴۰۹ subjects (۱۷۵ men, ۲۳۴ women) were randomly sample. Then each subject underwent a blood test, electrocardiography, medical examination and daily physical activity assessment. Nutrient intakes were obtained through assessment of food consumption as ۳-day recall. Personal information and anthropometric measurements were also recorded. Fast blood sugar & serum lipids were measured by auto analyzer Élan ۲۰۰۰; lipoprotein(a) by ELISA; hemocystein by HPLC; fibrinogen by turbidimetry and factor VII by calculating coagulation time compared to standard time. Statistical analyses were done by t-tests .The results showed that mean fibrinogen, factor VII, lipoprotein (a), and hemocystein were ۲۴۴.۹±۶۷ mg/dl, ۱۱۸.۳±۵۸ per cent, ۱۳.۳±۱۳ mg/dl and ۱۱.۵±۳ µmol/lit respectively in studied population. By comparing these new CVD risk factors over the world, it was determined that their levels were in the normal range in urban population of Isfahan. The level of fibrinogen and hemocystein are higher and lower in women than those in men respectively that is compatible with many other studies.

Keywords:

fibrinogen , Activity of factor VII , Lipoprotein (a) , Hemocystein , Thrombin