Occurrence of mucormycosis in association with Covid-۱۹ pandemic

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJMCM-13-2_001

تاریخ نمایه سازی: 18 اسفند 1402

Abstract:

Mucormycosis is a severe and potentially fatal fungal infection caused by opportunistic fungi belonging to the class Zygomycetes. Coronavirus ۲۰۱۹ (COVID-۱۹) is a severe worldwide disease. One of the problems faced by Covid-۱۹ patients is concurrent infection with microbial agents such as life-threatening fungal infections. Studies show that people with diabetes who have recovered from COVID-۱۹ are more likely to develop mucormycosis. In addition, patients with COVID-۱۹ are at increased risk of acute heart damage, arrhythmias, thromboembolic complication, and secondary infection. However, the exact reasons and mechanisms of increasing this deadly infection need to be investigated to understand the pathogenicity and discover reasonable ways of prevention and treatment. Studies show that increasing overuse of steroids, antibiotics, and zinc as an act of self-medication during the Covid-۱۹ epidemy may increase intestinal microbiota dysbiosis, thereby suppressing the system—immunity in the group at risk of this fungus. Ocular and cerebral mucormycosis is the most common form of the disease, with a mortality rate of over ۴۹%, especially in patients with pulmonary or diffuse or cerebral mucormycosis. In addition, a significant proportion of survivors of the disease showed symptoms such as ۴۶% vision loss. This article addresses potential mechanisms, host-related factors, pathogenicity, and innate and acquired immune system responses that may help understand the mystery of the sudden, severe, and fatal increase in mucormycosis infections due to Covid-۱۹. Early detection of such conditions with the above-mentioned consequences is vital for optimal treatment and better results.

Authors

Mojtaba Mohammadzadeh Vazifeh

Department of Microbial Biotechnology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran

Ayatollah Nasrollahi omran

Department of Medical Mycology , Faculty of Medicine, Tonekabon branch ,Islamic azad university, Tonekabon, Iran.

Seyed AmirAli Anvar

Department of Food Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran

nakisa Sohrabi Haghdoost

Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Reyhane Mirzamohammadi

Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Mohammad Paargari

Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran