Effects of Crocus sativus and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by PQ aerosol in rats

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-27-5_014

تاریخ نمایه سازی: 19 اسفند 1402

Abstract:

Objective(s): The effects of Crocus sativus, safranal, and pioglitazone on aerosolized paraquat (PQ)-induced systemic changes were examined.  Materials and Methods: Control (Ctrl) and PQ groups of rats were exposed to saline or PQ (۲۷ and ۵۴ mg/m۳, PQ-L and PQ-H) aerosols eight times on alternate days. Nine PQ-H groups were treated with dexamethasone (۰.۰۳ mg/kg/day, Dexa), two doses of C. sativus extract (۲۰ and ۸۰ mg/kg/day, CS-L and CS-H), safranal (۰.۸ and ۳.۲ mg/kg/day, Saf-L and Saf-H), pioglitazone (۵ and ۱۰ mg/kg/day, Pio-L and Pio-H), and the combination of low dose of the pioglitazone and extract or safranal (Pio + CS and Pio + Saf) after the end of PQ exposure. Results: Interferon-gamma (INF-γ), interleukin ۱۰ (IL-۱۰), superoxide dismutase (SOD), catalase (CAT), and thiol serum levels were reduced, but tumor necrosis factor (TNF-α), malondialdehyde (MDA), and total and differential WBC were increased in both PQ groups (P<۰.۰۵ to P<۰.۰۰۱). All measured variables were improved in all treated groups (P<۰.۰۵ to P<۰.۰۰۱). The effects of high dose of C. sativus and safranal on measured parameters were higher than dexamethasone (P<۰.۰۵ to P<۰.۰۰۱). The effects of  Pio + CS and Pio + Saf treatment on most variables were significantly higher than three agents alone (P<۰.۰۵ to P<۰.۰۰۱).Conclusion: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.

Authors

Arghavan Memarzia

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Ghasemi

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Amin

Physiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Zahra Gholamnezhad

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Hossein Boskabady

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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