Nano-selenium supplementation upregulate TLR-۷, MyD۸۸, NF-kB, and TRAF۶ genes in thymus of Wistar rats following treatment with cyclosporine A

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_NAMJ-11-2_003

تاریخ نمایه سازی: 27 اسفند 1402

Abstract:

Objective(s): Selenium Nanoparticles can modulate the function of the immune system and improve immunity. We investigate the expression of toll-like receptor-۷ (TLR-۷), myeloid differentiation primary response ۸۸ (MyD۸۸), Nuclear factor kappa B (NF-κB), and TNF receptor associated factor ۶ (TRAF۶) genes in thymus of Wistar rats following treatment with cyclosporine A (CsA) and Nano-selenium (Nano-Se) supplementation. Materials and Methods: Twenty-four male Wistar rats (۲۰۰-۲۲۰ grams) were divided into ۳ groups of control (n=۸), CsA (n=۸), and CsA+Nano-Se (n=۸). Rats in CsA and CsA+Nano-Se group’s received cyclosporine A and olive oil solution by subcutaneous injection for ۱۰ days at a dose of ۵ mg/kg/day. Nano-Se with a dose of ۲.۵ mg/kg of body weight was gavaged to the CsA+Nano-Se group once a day and ۳ times a week. Real-time PCR were used for gene expression of TLR-۷, MyD۸۸, NF-kB, and TRAF۶ at thymus. Results: The result of this study show that CsA significantly decreased expressions of TLR-۷, MyD۸۸, NF-kB, and TRAF۶ at thymus compared to control group (P<۰.۰۵). However, expressions of TLR-۷, MyD۸۸, NF-kB, and TRAF۶ at thymus in  CsA+ Nano-Se group was significantly increased compared to CsA group (P<۰.۰۵). Conclusion: Nano-Se supplementation significantly regulated the expression of TLR-۷, MyD۸۸, NF-kB and TRAF۶ genes in the thymus of rats treated with cyclosporine A. Therefore, Nano-Se supplementation can be recommended to boost immune function after using immunosuppressive drugs. However, more research is needed in the future.

Authors

Nafiseh Rezvani

Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran

Hossein Shirvani

Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Fatemeh Rostamkhai

Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran

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