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Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review

Publish Year: 1403
Type: Journal paper
Language: English
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JR_PBRE-10-1_007

Index date: 18 March 2024

Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review abstract

Background: There are only rare case reports that revealed the efavirenz (EFV) toxicity. Case Report: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were seen. Previous serious side effects of EFV were observed in HIV-infected patients who underwent long-term combination drug therapy.  Conclusion: Accordingly, in terms of the key clinical messages, serious adverse effects of efavirenz are expected to be observed in long-term use in combination with other antiretroviral drugs.

Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review Keywords:

Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review authors

Minoo Moghimi

Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Zahra Nekoukar

Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Navid Khosravi

Department of Emergency Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

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