Anti-neurodegenerative, anticancer, anti-inflammatory, and antiobesity activities of theaflavin and its derivatives
Publish place: Micro Nano Bio Aspects، Vol: 2، Issue: 4
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MNBA-2-4_002
تاریخ نمایه سازی: 23 اردیبهشت 1403
Abstract:
Polyphenol metabolites have several hydroxyl groups on aromatic rings. Flavonoids are the main natural groups of polyphenols with numerous therapeutic effects. Theaflavin and its derivatives (theaflavin ۳-gallate, theaflavin ۳,۳′-digallate, and theaflavin ۳′-gallate) as one of the major polyphenols of black tea have shown promising anticancer, anti-inflammatory, antiobesity, and anti-neurodegenerative activities. This bioactive compound has the potential capacity to ameliorate coronary heart disease and a healing impact on the density of bone minerals. The emergence of drug resistance in cancer cells and bacteria has caused more endeavors to find novel effective anticancer and antibacterial agents. In addition, recent studies aim to reduce severe side effects associated with chemotherapy and antimicrobials. In the case of neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson’s, the low efficiency of current expensive drugs is the main problem with therapy for these disorders. In this regard, discovering and designing new anti-neurodegenerative drugs is dispensable.
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Authors
Iraj Salimikia
Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Lorestan, Iran
Sargol Aminnezhad
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
Maral Maghsoudloo
Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana, USA
Foroogh Mirzania
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Lorestan, Iran