Effects of curcuminoids and resveratrol in micro and nanoformulations on brain-derived neurotrophic factor: A brief review

One of the main investigated neurotrophin proteins in the brain of the mammalian is brain-derived neurotrophic factor (BDNF). Learning, memory, and cognitive function are affected by the decrease of BDNF. Curcuminoids and resveratrol as the main herbal polyphenols, have significant potential in neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. The neuroprotective activities of curcuminoids and resveratrol and its ability to enhance BDNF levels have been reported in several trials. BDNF/tyrosine receptor kinase B (TrkB) signaling pathway is upregulated by curcumin treatment. Nanoformulations of curcuminoids and resveratrol by biocompatible and biodegradable nanomaterials can be considered as a novel strategy with adequate efficacy to improve the bioavailability of these polyphenols. In this way, this mini-review has been tried to address recent progress about both micro and nanoformulations of curcuminoids and resveratrol.

Keywords:

Neurodegenerative Diseases , BDNF , Neurotrophin proteins , TrkB signaling pathway , Biodegradable nanomaterials