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Recent Advances in the Treatment of Spinal Cord Injury

Publish place: The Archives of Bone and Joint Surgery، Vol: 12، Issue: 6
Publish Year: 1403
Type: Journal paper
Language: English
View: 140

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https://civilica.com/doc/1993140

Document National Code:

JR_TABO-12-6_002

Index date: 5 June 2024

Recent Advances in the Treatment of Spinal Cord Injury abstract

Spinal cord injury (SCI) is a complex, multifaceted, progressive, and yet incurable complication that can cause irreversible damage to the individual, family, and society. In recent years strategies for the management and rehabilitation of SCI besides axonal regeneration, remyelination, and neuronal plasticity of the injured spinal cord have significantly improved. Although most of the current research and therapeutic advances have been made in animal models, so far, no specific and complete treatment has been reported for SCI in humans. The failure to treat this complication has been due to the inherent neurological complexity and the structural, cellular, molecular, and biochemical characteristics of spinal cord injury. In this review, in addition to elucidating the causes of spinal cord injury from a molecular and pathophysiological perspective, the complexity and drawbacks of neural regeneration that lead to the failure in SCI treatment are described. Also, recent advances and cutting -edge strategies in most areas of SCI treatment are presented.  Level of evidence: I

Recent Advances in the Treatment of Spinal Cord Injury Keywords:

Combination therapy , Neural tissue engineering , Neuron , SCI , Spinal cord injury

Recent Advances in the Treatment of Spinal Cord Injury authors

Davood Yari

Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran - Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Arezoo Saberi

Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Salmasi

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran - Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad,

Seyed Alireza Ghoreishi

Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Department of Orthopedic Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Leila Etemad

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Jebrail Movaffagh

Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran - Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Babak Ganjeifar

Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

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