Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia: Application of SF-۳۶, EQ-۵D, and Visual Analogue Scale Measures

Background β-Thalassemia is a prevalent genetic disease in Mediterranean countries. The most common treatments for this disease are blood transfusion plus iron chelation (BTIC) therapy and bone marrow transplantation (BMT). Patients using these procedures experience different health-related quality of life (HRQoL). The purpose of the present study was to measure HRQoL in these patients using ۲ different multiattribute quality of life (QoL) scales.   Methods In this cross-sectional study, data were gathered using ۳ instruments: a socio-demographic questionnaire, EQ-۵D, and SF-۳۶. A total of ۱۹۶ patients with β-thalassemia were randomly selected from ۲ hospitals in Shiraz (Southern Iran). Data were analyzed using logistic regression and multiple regression models to identify factors that affect the patients’ HRQoL.   Results The average EQ-۵D index and EQ visual analog scale (VAS) scores were ۰.۸۶ (۹۵% CI: ۰.۸۳–۰.۸۹) and ۷۱.۸۵ (۹۵% CI: ۶۹.۱۳–۷۴.۵۸), respectively. Patients with BMT reported significantly higher EQ VAS scores (۸۳.۲۷ vs ۶۸.۵۵, respectively). The results showed that patients who lived in rural area and patients with BMT reported higher EQ VAS scores (rural; β=۱۰.۲۵, P=.۰۰۶ and BMT; β=۱۱.۸۸, P=.۰۰۰). As well, SF-۳۶ between ۲ groups of patients were statistically significant in physical component scale (PCS).   Conclusion Patients in the BMT group experienced higher HRQoL in both physical and mental aspects compared to those in the BTIC group. More studies are needed to assess the relative cost-effectiveness of these methods in developing countries

Keywords:

β-Thalassemia , Health Related Quality of Life (HRQoL) , Blood Transfusion , Bone Marrow , Transplantation (BMT)