Recent Developments in RNA Therapeutics for Humans Disorders
Publish place: Personalized Medicine Journal، Vol: 9، Issue: 34
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_PMJ-9-34_001
تاریخ نمایه سازی: 6 شهریور 1403
Abstract:
Recent research has uncovered a wide range of RNAs, including noncoding RNAs, and have discovered their varied modes of action inside cells. These ribonucleic acids (RNAs) play a crucial role in controlling many cellular processes and are thus anticipated to be significant targets for the treatment of human disorders. In recent years, RNA-based medicinal approaches have made significant advancements alongside their comprehensive functional research. Following extensive study and experimentation, medications based on antisense RNAs and small interfering RNAs have been successfully created and are already being used in clinical settings. Furthermore, there is now ongoing research focused on the development of pharmaceuticals using RNA aptamers and messenger RNA. In addition to the advancement of RNA-based medications, many techniques have been devised to effectively deliver RNA drugs into cells. RNA treatment offers several benefits compared to current therapeutics based on small molecules or monoclonal antibodies, mostly due to its ability to selectively target all genes inside cells. The purpose of this article is to provide an overview of the introduction of various RNA-based technologies and the introduction of RNA-based drugs in the market. In addition, the future prospects of RNA therapy will be addressed.
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Authors
Farnaz Roshan Mehr
Department of Medical Biotechnology, Golestan University of Medical Sciences, Gorgan, Iran
Fatemeh Gabeleh
Department of Medical Virology, Tarbiat Modares University, Tehran, Iran
Roshanak Jazayeri
Non-communiable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran