CircRNAs: Biogenesis, identification and expression analysis

Publish Year: 1404
نوع سند: مقاله ژورنالی
زبان: English
View: 40

This Paper With 17 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_CMBR-5-1_006

تاریخ نمایه سازی: 16 مهر 1403

Abstract:

Circular ribonucleic acids (CircRNAs) represent a category of noncoding RNAs characterized by a circular structure bonded through covalent bonds. Unlike linear RNAs, CircRNAs are not affected by exonucleases and exhibit more stable expression. Research suggests that CircRNAs may have the ability to be translated through the internal ribosome entry sites (IRESs) mechanism and it could enable CircRNAs to produce proteins despite lacking a ۵' cap structure.  They have gained attention due to their diverse functions, including acting as miRNA sponges, participating in complex gene expression regulation, and disease markers. CircRNAs play crucial roles in various biological processes, including cancer development and progression.  These cyclic molecules have garnered significant interest for their diverse effects in humans. Furthermore, CircRNAs have been implicated in human genetic diseases, offering insights into potential diagnostic and therapeutic avenues. They are formed through back-splicing of pre-mRNA transcripts, resulting in covalently closed loops. Recent studies have highlighted the significance of CircRNAs in cancer biology, such as their involvement in modulating gene expression, acting as micro RNA (miRNA) sponges, and regulating cellular processes. There are some detection methods including computational models, experimental techniques, and advanced RNA-based and CLIP-Seq-based methods. This review could help to understand the key points regarding biogenesis, biological function, literature trend and biological function of CircRNAs.

Authors

Esmaiel Azizzad Ranji

Department of Biotechnology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran

Danial Kahrizi

Department of Biotechnology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran

Masomeh Khanahmadi

Department of Chemistry, Academic Center for Education, Culture and Research (ACECR), Kermanshah, Iran

Sajad Rashidi Monfared

Department of Biotechnology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Pisignano G, Michael DC, Visal TH, Pirlog R, Ladomery M, ...
  • Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, ...
  • Razouk A, Tiganescu E, von Glahn AJ, Abdin AY, Nasim ...
  • Ye Y, Guo W, Ngo HH, Wei W, Cheng D, ...
  • Goina CA, Goina DM, Farcas SS, Andreescu NI (۲۰۲۴) The ...
  • Hwang HJ, Kim YK (۲۰۲۴) Molecular mechanisms of circular RNA ...
  • Chen X, Yang T, Wang W, Xi W, Zhang T, ...
  • Hoque P, Romero B, Akins RE, Batish M (۲۰۲۳) Exploring ...
  • Jiang W, Yu Y, Ou J, Li Y, Zhu N ...
  • Nigro JM, Cho KR, Fearon ER, Kern SE, Ruppert JM, ...
  • Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO ...
  • Cheng L, Liu Z, Xia J (۲۰۲۳) New insights into ...
  • Chen X, Huang J, Peng Y, Han Y, Wang X, ...
  • Mecozzi N, Nenci A, Vera O, Bok I, Falzone A, ...
  • Chan RT, Peters JK, Robart AR, Wiryaman T, Rajashankar KR, ...
  • Wan R, Yan C, Bai R, Huang G, Shi Y ...
  • Ma Y, Liu Y, Jiang Z (۲۰۲۰) CircRNAs: A new ...
  • Wang Y, Wang Z (۲۰۱۵) Efficient backsplicing produces translatable circular ...
  • Liang D, Tatomer DC, Luo Z, Wu H, Yang L, ...
  • Zhao W, Chu S, Jiao Y (۲۰۱۹) Present Scenario of ...
  • Chen YY, Luo LP, Deng KC (۲۰۲۳) Circular RNA LPAR۳ ...
  • Sun H, Xu F, You D (۲۰۲۳) CircPI۴KA Overexpression Enhances ...
  • Zhu H, Yang W, Cheng Q, Yang S (۲۰۲۲) Circ_۰۰۱۰۲۳۵ ...
  • Lu Q, Sun H, Yu Q, Tang D (۲۰۲۳) Circ_PRDM۵/miR‐۲۵‐۳p/ANKRD۴۶ ...
  • Liu F, Gao B, Wang Y (۲۰۲۲) CircIRAK۱ aggravates ox-LDL-induced ...
  • Capel B, Swain A, Nicolis S, Hacker A, Walter M, ...
  • Zhang X-O, Wang H-B, Zhang Y, Lu X, Chen L-L, ...
  • Lu T, Cui L, Zhou Y, Zhu C, Fan D, ...
  • Ebrahimi A, Aghbabayi M, Rashidi-Monfared S, Charkhabi NF, Gharanjik S, ...
  • Kakeshpour T, Nayebi S, Rashidi Monfared S, Moieni A, Karimzadeh ...
  • Poursalavati A, Rashidi-Monfared S, Ebrahimi A (۲۰۲۱) Toward understanding of ...
  • Abedini D, Rashidi Monfared S (۲۰۱۸) Co-regulation analysis of co-expressed ...
  • Abedini D, Monfared SR, Abbasi A (۲۰۱۸) The effects of ...
  • Davoodi Mastakani F, Pagheh G, Rashidi Monfared S, Shams-Bakhsh M ...
  • Franco-Zorrilla JM, Valli A, Todesco M, Mateos I, Puga MI, ...
  • Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, ...
  • Peijing Z, Sida L, Ming C (۲۰۲۰) Characterization and Function ...
  • Conn VM, Hugouvieux V, Nayak A, Conos SA, Capovilla G, ...
  • Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti ...
  • Babayev M, Silveyra P (۲۰۲۴) Role of circular RNAs in ...
  • Gu A, Jaijyan DK, Yang S, Zeng M, Pei S, ...
  • Liu Q, Wang Y, Zhang T, Fang J, Meng S ...
  • Quan G, Li J (۲۰۱۸) Circular RNAs: biogenesis, expression and ...
  • Yehui L, Zhihong L, Fang T, Zixuan Z, Mengyuan Z, ...
  • Sheng JQ, Liu L, Wang MR, Li PY (۲۰۱۸) Circular ...
  • Bhat AA, Gupta G, Goyal A, Thapa R, Almalki WH, ...
  • Drula R, Braicu C, Chira S, Berindan-Neagoe I (۲۰۲۳) Investigating ...
  • Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, ...
  • Fonseca NA, Rung J, Brazma A, Marioni JC (۲۰۱۲) Tools ...
  • Danan M, Schwartz S, Edelheit S, Sorek R (۲۰۱۲) Transcriptome-wide ...
  • Arick M, ۲nd, Hsu CY (۲۰۱۸) Differential Gene Expression Analysis ...
  • Metge F, Czaja-Hasse LF, Reinhardt R, Dieterich C (۲۰۱۷) FUCHS-towards ...
  • Asghari H, Lin YY, Xu Y, Haghshenas E, Collins CC, ...
  • Nguyen MH, Nguyen H-N, Vu TN (۲۰۲۲) Evaluation of methods ...
  • Nguyen DT, Trac QT, Nguyen T-H, Nguyen H-N, Ohad N, ...
  • Niu M, Wang C, Chen Y, Zou Q, Qi R, ...
  • Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, ...
  • Buratin A, Bortoluzzi S, Gaffo E (۲۰۲۳) Systematic benchmarking of ...
  • Tian J, Fu Y, Li Q, Xu Y, Xi X, ...
  • Gao Y, Zhang J, Zhao F (۲۰۱۸) Circular RNA identification ...
  • Zhong S, Wang J, Zhang Q, Xu H, Feng J ...
  • Westholm JO, Miura P, Olson S, Shenker S, Joseph B, ...
  • Yang XS, Wu J, Ziegler TE, Yang X, Zayed A, ...
  • نمایش کامل مراجع