سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

A Discovery to Figure out Toxicity Mechanism in TBI Models

Publish Year: 1397
Type: Conference paper
Language: English
View: 38
این Paper فقط به صورت چکیده توسط دبیرخانه ارسال شده است و فایل کامل قابل دریافت نیست. برای یافتن Papers دارای فایل کامل، از بخش [جستجوی مقالات فارسی] اقدام فرمایید.

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Export:

Link to this Paper:

Document National Code:

SCROYAN14_095

Index date: 3 November 2024

A Discovery to Figure out Toxicity Mechanism in TBI Models abstract

Background: Traumatic brain injury (TBI) has been suggestedas the biggest risk factor for chronic neurodegenerative disorders;such as Alzheimer’s disease and amyotrophic lateral sclerosis.It has been shown that phosphorylated tau at Thr231 inthe cis conformation is the central mediator of cell death upontauopathy. Besides, cis p-tau is being considered as the earliesttau epitope; ahead of any oligomer, aggregate and tangleepitopes, resulting in cell death. Also, neurons treated with TBIbrain lysates had much higher rate of apoptosis. Thus, cis p-tauis indeed neurotoxic and plays key role in neurodegenerationupon tauopathy and TBI.Materials and Methods: To test the hypothesis, TBI mousebrains were immunostained with cis p-tau.Results: We have found that neurotoxic cis p-tau initially movesinto nucleus in the TBI brains; causing cell death in a time dependentmanner. Thus, we hypothesized that cis p-T231-tau isbecoming neurotoxic upon its nuclear translocation. To test thehypothesis, TBI mouse brains were immunostained with cis ptau.Our results demonstrated that the neurotoxic cis, but nottrans, pT231-tau moves into nucleus. Furthermore, cis p-tauplays its pathogenic roles upon its translocation.Conclusion: Taking these together, we concluded that cis p-taukills the cells through some physiological processes interruption;likely by interacting with nuclear factors. Our data opennew windows toward understanding tauopathy and TBI molecularmechanisms and further may shed light to possible treatmentsfor neurodegenerative disorders.

A Discovery to Figure out Toxicity Mechanism in TBI Models Keywords:

A Discovery to Figure out Toxicity Mechanism in TBI Models authors

Sh Roghanian Ghazvini

Department of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran- Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

K Shahpasand

Department of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Sh Ahmadian

Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran