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The Role of miRNAs as Diagnostic and Therapeutic Biomarkers in Lung Cancer

Publish Year: 1403
Type: Preprint paper
Language: English
View: 106

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Link to this Preprint:
https://civilica.com/doc/2113137

Document National Code:

pre-2113137

Index date: 6 November 2024

The Role of miRNAs as Diagnostic and Therapeutic Biomarkers in Lung Cancer abstract

This study examines the role of miRNAs as diagnostic and therapeutic biomarkers in lung cancer, a disease with a notably high mortality rate that poses a significant medical challenge worldwide. Given the need for precise diagnostic and therapeutic strategies, miRNAs have emerged as promising candidates. Due to their stability in various body fluids and their critical roles in tumorigenesis and drug resistance, miRNAs are increasingly recognized as reliable, non-invasive biomarkers for early detection, prognosis, and disease progression assessment. This research presents a comprehensive analysis of oncogenic miRNAs, including miR-21 and miR-155, as well as tumor-suppressor miRNAs such as let-7 and miR-34, underscoring their diagnostic and therapeutic significance in lung cancer. Additionally, this study explores innovative approaches to target and deliver miRNAs into cancer cells, offering new avenues for treatment. The findings suggest that miRNAs hold substantial potential as effective tools for lung cancer management, aiding in both early intervention and the reduction of drug resistance.

The Role of miRNAs as Diagnostic and Therapeutic Biomarkers in Lung Cancer Keywords:

microRNAs , Lung Cancer , Biomarkers , Non-invasive Diagnosis , Therapeutic Targets

The Role of miRNAs as Diagnostic and Therapeutic Biomarkers in Lung Cancer authors

Soheil Nasiri Kalshani

دانشجوی رشته زیست سلولی و مولکولی دانشگاه آزاد واد پرند

Mitra Heydari Nasr Abadi

میترا حیدری نصر آبادی عضو هیئت علمی دانشگاه آزاد اسلامی واحد پرند

Seyyed Fazel Shamsa

سید فاضل شمسا عضو هیئت علمی دانشگاه تهران واحد علوم پزشکی تهران

Nastaran Asghari Moghadam

نسترن اصغری مقدم عضو هیئت علمی دانشگاه آزاد اسلامی واحد تهران مرکزی

مقدمه/پیشینه تحقیق

Lung cancer is one of the most common and dangerous cancers, often associated with poor prognosis and drug resistance due to its aggressive nature and late diagnosis. In the quest for precise and non-invasive solutions, research has shifted toward using miRNAs as molecular biomarkers and innovative therapeutic tools. As non-coding RNAs, miRNAs regulate genes involved in tumorigenesis, metastasis, and drug resistance. Oncogenic and tumor-suppressor miRNAs, such as miR-21, miR-155, let-7, and miR-34, play roles in various cancer-related processes and are valuable non-invasive biomarkers due to their presence in body fluids. This study aims to review and analyze the role of miRNAs in lung cancer as diagnostic and therapeutic biomarkers and to provide an outlook on their potential in novel therapeutic approaches.

روش ها

This research was conducted through a systematic review of reputable scientific databases, including PubMed, Scopus, and Web of Science. Using keywords such as "miRNA in lung cancer," "diagnostic miRNA biomarkers," and "miRNA-based therapy," 50 relevant articles were selected and reviewed. Inclusion criteria consisted of original research and review articles focusing on the role of oncogenic and tumor-suppressor miRNAs in lung cancer diagnosis and treatment. All extracted data were categorized and analyzed based on the miRNAs' impact on tumorigenesis, drug resistance, early detection, and prognosis.

نتیجه گیری

This study demonstrates that miRNAs play a critical role in tumorigenesis and drug resistance processes and can serve as diagnostic tools and novel therapeutic targets in lung cancer. Oncogenic miRNAs, such as miR-21 and miR-155, enhance drug resistance and tumor progression by suppressing tumor-suppressor genes and activating survival pathways. In contrast, tumor-suppressor miRNAs like let-7 and miR-34 offer a better prognosis for patients by inhibiting cell proliferation and inducing apoptosis. Due to their stability in body fluids, miRNAs can be detected non-invasively, making them effective diagnostic biomarkers. Additionally, using miRNAs in cancer-targeted therapies, such as nanoparticle and viral delivery systems, presents a promising approach for reducing drug resistance and improving treatment efficacy. This research underscores the need for the development of targeted strategies to control lung cancer and highlights the pivotal role of miRNAs in this process.

مراجع و منابع این Preprint:

لیست زیر مراجع و منابع استفاده شده در این مقاله پیش چاپ را نمایش می دهد. برخی از مراجع این مقاله ممکن است قبلا در سیویلیکا نمایه شده باشند، در این صورت مراجع مورد نظر به صورت کاملا ماشینی و بر اساس هوش مصنوعی و بدون دخالت انسانی استخراج شده و به مقاله یا منبع مذکور لینک میشوند
1. Shajari, E., & Mollasalehi, H. (2020). Ribonucleic-acid-biomarker candidates for early-phase ...
2. Pop-Bica, C., Pintea, S., Magdo, L., Cojocneanu, R., Gulei, D., ...
3. Yi, M., Liao, Z., Deng, L., Xu, L., Tan, Y., ...
4. Sima, M., Rossnerova, A., Simova, Z., & Rossner Jr., P. ...
5. Zhu, Z., Li, Q., Xu, M., & Qi, Z. (2020). ...
6. Sweef, O., Zaabout, E., Bakheet, A., Halawa, M., Gad, I., ...
7. Canatan, D., Sönmez, Y., Yılmaz, Ö., Coşkun, H. Ş., Göksu, ...
8. Wu, S.-G., Chang, T.-H., Liu, Y.-N., & Shih, J.-Y. (2019). ...
9. Gayosso-Gómez, L. V., & Ortiz-Quintero, B. (2021). Circulating microRNAs in ...
10. Huang, Y., Hu, Q., Deng, Z., Hang, Y., Wang, J., ...
11. Wadowska, K., Bil-Lula, I., Trembecki, Ł., & Śliwińska-Mossoń, M. (2020). ...
12. Letelier, P., Saldías, R., Loren, P., Riquelme, I., & Guzmán, ...
13. Seijo, L. M., Peled, N., Ajona, D., Boeri, M., Field, ...
14. Del Vescovo, V., Grasso, M., Barbareschi, M., & Denti, M. ...
15. Joshi, P., Middleton, J., Jeon, Y.-J., & Garofalo, M. (2014). ...
16. Mukhopadhyay, D., Cocco, P., Orrù, S., Cherchi, R., & De ...
17. Messina, S. (2024). The RAS oncogene in brain tumors and ...
18. Sadeghi, M. S., Lotfi, M., Soltani, N., Farmani, E., Ortiz ...
19. Peng, J., Liu, J., Liu, H., Huang, Y., & Ren, ...
20. Shadbad, M. A., Ghorbaninezhad, F., Hassanian, H., Ahangar, N. K., ...
21. Khalilian, S., Abedinlou, H., Hussen, B. M., Imani, S. Z. ...
22. Hassanein, S. S., Ibrahim, S. A., & Abdel-Mawgood, A. L. ...
23. Roufayel, R., & Kadry, S. (2020). MicroRNAs: Crucial regulators of ...
24. Li, J., Zhong, X., Zhao, Y., Shen, J., Pilapong, C., ...
25. Canale, M., Pasini, L., Bronte, G., Delmonte, A., Cravero, P., ...
26. Bersimbaev, R., Bulgakova, O., Aripova, A., Kussainova, A., & Ilderbayev, ...
27. Veryaskina, Y. A., Titov, S. E., & Zhimulev, I. F. ...
28. Hua, C., Hui, K., & Jiang, X. (2020). Effects of ...
29. Chen, J., Wu, F., Hou, E., Zeng, J., Li, F., ...
30. Migdalska-Sęk, M., Modrzewska, B., Kordiak, J., Pastuszak-Lewandoska, D., Kiszałkiewicz, J. ...
31. Cuttano, R., Afanga, M. K., & Bianchi, F. (2022). MicroRNAs ...
32. Xu, L., Huang, X., Lou, Y., Xie, W., & Zhao, ...
33. Braga, E. A., Fridman, M. V., Burdennyy, A. M., Loginov, ...
34. Le, M. T., Nguyen, H. T., Nguyen, X. H., Do, ...
35. Ramazi, S., Daddzadi, M., Sahafnejad, Z., & Allahverdi, A. (2023). ...
36. Petrek, H., & Yu, A.-M. (2019). MicroRNAs in non-small cell ...
37. Duréndez-Sáez, E., Torres-Martinez, S., Calabuig-Fariñas, S., Meri-Abad, M., Ferrero-Gimeno, M., ...
38. Cavallari, I., Ciccarese, F., Sharova, E., Urso, L., Raimondi, V., ...
39. Sweef, O., Zaabout, E., Bakheet, A., Halawa, M., Gad, I., ...
40. Messina, S. (2024). The RAS oncogene in brain tumors and ...
41. Peng, J., Liu, J., Liu, H., Huang, Y., & Ren, ...
42. Shadbad, M. A., Ghorbaninezhad, F., Hassanian, H., Ahangar, N. K., ...
43. Khalilian, S., Abedinlou, H., Hussen, B. M., Imani, S. Z. ...
44. Hassanein, S. S., Ibrahim, S. A., & Abdel-Mawgood, A. L. ...
45. Roufayel, R., & Kadry, S. (2020). MicroRNAs: Crucial regulators of ...
46. Li, J., Zhong, X., Zhao, Y., Shen, J., Pilapong, C., ...
47. Canale, M., Pasini, L., Bronte, G., Delmonte, A., Cravero, P., ...
48. Favier, A., Rocher, G., Larsen, A. K., Delangle, R., Uzan, ...
49. Sweef, O., Zaabout, E., Bakheet, A., Halawa, M., Gad, I., ...
50. Cavallari, I., Ciccarese, F., Sharova, E., Urso, L., Raimondi, V., ...
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