A review of PHBV-based scaffolds for application in cartilage tissue engineering

Tissue engineering technology facilitates the regeneration of new tissue to replace damaged or scarred tissue. Biodegradable and porous 3D scaffolds are commonly utilized to replicate the structure and function of the extracellular matrix in this fieldFor in vitro and in vivo cell seeding, scaffold materials and design are the ideal materials, and they are important areas of biomaterial research. PHAs, or polyhydroxyalkanoates, are bio-based polyesters that are thermoplastic and have garnered a lot of interest because of their mechanical qualities, non-toxicity, enhanced biocompatibility, and capacity to be heat processed. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), or PHBV, is a member of the PHA family and has garnered significant interest in the field of medical applications recently because of its exceptional biocompatibility, minimal cytotoxicity, and bioactive characteristics. They also have a great deal of potential for modification through chemical, biological, and physical changes. However, PHBV has certain drawbacks that prevent it from being widely used for commercial purposes. These drawbacks include poor mechanical properties, low thermal stability, challenging processability, and significant hydrophobicity. Many studies have concentrated on enhancing its properties through the creation of composites and applying the resulting composites for a variety of applications in an effort to get around these restrictions. This article's goal is to review polyhydroxybutyrate valerate-based composite and nanocomposite scaffolds for use in cartilage tissue engineering.

A review of PHBV-based scaffolds for application in cartilage tissue engineering Keywords:

PHAs , PHBV , Cartilage tissue engineering