Evaluation Of The Preventive Function Of Ferulic Acid On Neuroinflammation And Oxidative Stress In The Kainic Acid-Induced Temporal Lobe Epilepsy Model In Mice

Temporal lobe epilepsy was considered as an incurable disease with not clearly defined mechanisms. Ferulic acid (FA) have shown anti-inflammatory, antioxidant and neuroprotective potentials. The aim of this study is evaluating the effect of FA on kainic acid (KA)-induced seizure, and a well known neuroinflammatory and oxidative stress mediator in hippocampus of mice. Materials & Methods: Sixty male mice (25 to 30 g) were divided into 6 groups. Control: received normal saline (NS:1 ml/kg body weight, intraperitoneally (i.p)), KA (10 mg/kg, i.p), FA (20 and 80 mg/kg, i.p) daily for 7 days, FA (20 and 80 mg/kg, i.p) + KA (10 mg/kg, i.p) daily for 7 days. Animal Convulsive behaviors were recorded up to 2 hours after KA injection. Further, interleukin 1beta (IL-1β) and carbonyl protein (CP) levels were determined in homogenate of mice hippocampus immediately after behavioral tests. Results: The injection of KA led to seizure and increased IL-1 β and CP content in mice hippocampus. Pretreatment with FA at both doses suppressed the seizure and associated increase in hippocampal IL-1β and CP in mice. Conclusion: Our results suggest that pretreatment with FA not only inhibited KA-induced seizures, but also suppressed the seizure targeted effects on IL-1β and CP production in the hippocampus. Therefore, FA can protect temporal lobe epilepsy in mice by modulating inflammatory factors and oxidative stress in the hippocampus.

Evaluation Of The Preventive Function Of Ferulic Acid On Neuroinflammation And Oxidative Stress In The Kainic Acid-Induced Temporal Lobe Epilepsy Model In Mice Keywords:

Epilepsy , Neuroinflammation , Oxidative stress , Ferulic acid , Mice