The Role of BRCA۱ and BRCA۲ Genes and Helicobacter pylori in Gastric CancerDevelopmen

This research underscores the significant impact of BRCA۱ and BRCA۲ gene mutations and Helicobacter pyloriinfection on gastric cancer development. Mutations in these critical genes compromise DNA repair processes,resulting in genetic instability and a heightened risk of malignancy. Furthermore, the CagA-positive strain of H.pylori exacerbates cancer progression by disrupting BRCA۱ function and fostering carcinogenesis. Exploring thecomplex interaction between genetic predisposition and bacterial infection provides valuable perspectives foradvancing prevention, diagnosis, and therapeutic approaches in gastric cancer.

Keywords:

Gastric cancer , BRCA۱ , BRCA۲ , genetic mutation , Helicobacter pylori