Detection of Alzheimer’s Disease Using Multitracer Positron Emission Tomography Imaging

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJE-27-1_016

تاریخ نمایه سازی: 17 خرداد 1393

Abstract:

Alzheimer's disease is characterized by impaired glucose metabolism and demonstration of amyloid plaques. Individual positron emission tomography tracers may reveal specific signs of pathology that isnot readily apparent on inspection of another one. Combination of multitracer positron emissiontomography imaging yields promising results. In this paper, 57 Alzheimer's disease neuroimaging initiative subjects that had FDG and PiB-positron emission tomography neuroimaging scans at the same time were used for development of proposed multitracer classification method. The subject’sbrain image was automatically parcellated into 48 pre-defined regions of interest. Then, 96 features were extracted for each subject. The principal features weere extracted using principal component analysis, then they were combined based on intersection strategy. Finally, a support vector machinewas adopted to evaluate the classification accuracy. Combination of two tracers with positron emissiontomography scan yielded a higher diagnostic accuracy in Alzheimer's disease compared to individual tracer and other combination methods

Authors

h dehghan

School of Computer Engineering and Information Technology, Shahrood University of Technology, Shahrood, Iran

a.a pouyan

School of Computer Engineering and Information Technology, Shahrood University of Technology, Shahrood, Iran

h hassanpour

School of Computer Engineering and Information Technology, Shahrood University of Technology, Shahrood, Iran