The ways of preventing Alzheimer; a systematic review

Background and Aim: Alzheimer is the most prevalent age-related neurodegenerative disease, is clinically characterized by a progressive loss of memory and other cognitive functions. Preventing Alzheimer disease (AD) is a worthy cause for many reasons. The first is the sheer number of those suffering with AD. The second reason is that without intervention, the number of individuals with AD will skyrocket in the coming decades. The third reason is that AD currently does not have a cure or even an effective disease-modifying drug. Also AD prevention is the second major wave of preventive efforts in the field of neurology. The first wave was stroke prevention. Methods: We searched pubmed, Google scholar, Scopus and other related data bases up to December ۲۰۱۹ and we find ۱۲ articles with our criteria. A wide variety of prevention parameters were explored. And also the best ways of preventing Alzheimer was reviewed. Results: Our primary goal was to identify the possibility of preventing Alzheimer and how we can do it and with which strategies. Conclusion: Results from ongoing observational and intervention studies focused specifically on AD/cognitive impairment can contribute to identifying effective preventive strategies tailored to different groups at risk of dementia (i.e. defined according to age, vascular/metabolic/lifestyle profiles, various biological markers and cognitive status). Also studies represent that the relation between neuropathological changes and cognitive impairment is not well understood. For better treatment and prevention, more studies about this topic is recommended.

Keywords:

Alzheimer prevention , treatment , dementia