Nonfunctional Adrenocortical Carcinoma with Foci of Osseous Metaplasia in a Young Girl
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 7، Issue: 2
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-7-2_010
تاریخ نمایه سازی: 5 آبان 1393
Abstract:
Nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. Unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. Here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. No hypertension and cushingoid features were seen. Serum alpha-fetoprotein, urine vanillyl mandelic acid and homovanillic acid levels were not elevated. CT scan showed multiple pulmonary nodules suggestive of metastatic deposits. With gross and light microscopic findings differential diagnoses of hepatoblastoma, paraganglioma, renal cell carcinoma, adrenal cortical and medullary tumours were made. An array of immunohistochemical markers was done and the final diagnosis given was nonfunctional adrenocortical carcinoma with foci of osseous metaplasia.
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Authors
Srilatha Parampalli Srinivas
Dept. of Pathology, Melaka Manipal Medical College, Manipal University, Manipal, India
Alfred Roy
Dept. of Pathology, KMC International Centre, Manipal University, Manipal, India
Vijay kumar
Dept. of Paediatric Surgery, Kasturba Medical College and Hospital, Manipal University, Manipal, India