Preparation of Miconazole Nanoparticles Using Rapid Expansion of Supercritical Solution

Miconazoleis a broad-spectrum antifungal drug of the imidazole group, which comes in various forms,including oral, parenteral, and transdermal formulations with low solubility in water. In this paper we report on theformation of miconazole nanoparticles by rapid expansion of supercritical solutions (RESS). The unprocessed andprocessed miconazole powder was characterized by means of scanning electron microscopy (SEM). SEM images showthat the RESS processing of miconazole leads to nanoparticles with spherical shape.

Keywords:

Ultrafine Particles , Miconazole , Rapid Expansion of Supercritical Solution