Computer Modeling Study of Effect of Gelatin-Chitosan Scaffold on Retinal Detachment
Publish place: International Conference on New Research Findings in Chemistry and Chemical Engineering
Publish Year: 1394
Type: Conference paper
Language: English
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Document National Code:
CHCONF01_180
Index date: 10 January 2016
Computer Modeling Study of Effect of Gelatin-Chitosan Scaffold on Retinal Detachment abstract
Age-related Macular Degeneration is the major cause of vision loss after age 50 in the world. AMD is characterized by loss of the retinal pigment epithelium within the macula. In retinal tissue engineering, gelatin-chitosan scaffold is replaced in the Bruch’s membrane and suitable environment prepared to RPE cell growth. This scaffold may cause retinal detachment. Therefore, the factors create retinal detachment with scaffold should be investigated. In this study, two factors including intraocular pressure and retinal strain were investigated. In order to investigating these factors, gelatin-chitosan scaffold, RPE and retinal cells by using COMSOL software were simulated. The results show, 1) IOP equal 1668.481 Pa, this pressure is in the range of normal IOP. 2) Retinal strain was calculated as 0.1163, this strain is lesser than frailer strain. This simulation illustrate that gelatin-chitosan scaffold don’t cause retinal detachment.
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Computer Modeling Study of Effect of Gelatin-Chitosan Scaffold on Retinal Detachment authors
F Babaour
Factually of New Science and Technologies, University of Tehran, P.O. Box ۱۴۳۹۵-۱۵۶۱, Tehran, Iran.
F Yazdian
Factually of New Science and Technologies, University of Tehran, P.O. Box ۱۴۳۹۵-۱۵۶۱, Tehran, Iran.
F Tabandeh
Factually of New Science and Technologies, University of Tehran, P.O. Box ۱۴۳۹۵-۱۵۶۱, Tehran, Iran.
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