Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents

Bahador Shahriari; Zahra Rezaei; Soghra Khabnadideh; Hossein Sadeghpour

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Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents

Publish place: Trends in Pharmaceutical Sciences، Vol: 1، Issue: 2

Publish Year: 1394

Type: Journal paper

Language: English

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https://civilica.com/doc/450771

Document National Code:

JR_TIPS-1-2_007

Index date: 5 April 2016

Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents abstract

Nitroimidazole derivatives such as Metronidazole (MTZ) have been used as anti- protozoa and anti-anaerobic bacteria. In this study several derivatives of MTZ were synthesized and evaluated against Giardia lamblia cyst. MTZ were reacted with several alkyl halide to obtain o-alkyl MTZ derivatives,then products were purified and their chemical structures were confirmed by spectral analysis (1HNMR and Mass). In order to assess biological evaluation, all compounds were investigated against 25 Giardia samples isolated from Giardia-infected patients. Results showed that compound 2 had the most activity on cyst of Giardia in comparison with MTZ.

Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents Keywords:

Nitromidazole , Metronidazole derivatives , Antigiarida

Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents authors

Bahador Shahriari

Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Zahra Rezaei

Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran

Soghra Khabnadideh

Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran

Hossein Sadeghpour

Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran

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I'm the author of the paper

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Link to this Paper:

https://civilica.com/doc/450771

Document National Code:

JR_TIPS-1-2_007

Index date: 5 April 2016

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Shahriari, Bahador and Rezaei, Zahra and Khabnadideh, Soghra and Sadeghpour, Hossein,1394,Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents,https://civilica.com/doc/450771

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Scientometrics

The specifications of the publisher center of this Paper are as follows:

Ranking of Shiraz University of Medical

Type of center: علوم پزشکی

Paper count: 3,615

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