Is There a Place for Round and Elongated Spermatids Injection inAssisted Reproduction?
Publish Year: 1382
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-1-1_001
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Spermatids are the earliest male germ cells with one set of haploid chromosomes. Afterexperiments, mainly in rodents, the spermatid injection was introduced in human assistedreproduction to the treatment of men with non-obstructive azoospermia. Spermatid injection is atechnique with particular difficulties that may negatively influence the outcome. The identification,isolation and the assessment of viability, especially for round spermatids, require intensive workand considerable experience. Up to date, it appears that the rates of fertilization and implantationwith round spermatid injection are dramatically low and significantly less compared to the use ofelongated spermatid injection. The extremely low fertilization potency of the round spermatids ledto attempts for their in-vitro culture and maturation. The immaturity of round and elongatedspermatids has raised concerns regarding the potential genetic risk for the offspring. Under thesefacts, a reconsideration of the use of spermatids in assisted human reproduction is necessary
Authors
Byron Asimakopoulos
Laboratory of Reproductive Physiology - IVF, Faculty of Medicine, Democritus Univ. of Thrace, Dragana, ۶۸۱۰۰ Alexandroupolis, Greece - Hellas.
Nikos Nikolettos
Laboratory of Reproductive Physiology - IVF, Faculty of Medicine, Democritus Univ. of Thrace, Dragana, ۶۸۱۰۰ Alexandroupolis, Greece - Hellas.
Safa Al-Hasani
Department of Obstetrics/Gynecology, Universitat zu Schleswig-Holstein,Ratzerburger Allee ۱۶۰, D-۲۳۵۳۸ Lübeck, Germany.