Comparison of serum levels of Tri‐iodothyronine (T3),Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-10-1_008
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Background: The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia.Objective: The aim of this study was comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy.Materials and Methods: In this case‐control study, 40 normal pregnant women and 40 cases of preeclampsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 (FT3), Free T4 (FT4) and TSH. The data was analyzed by SPSS software with the use of t‐student, Chi‐square, Independent sample T-test and Bivariate correlation test. p≤0.05 was considered statistically significant.Results: The mean age was not statistically different between two groups (p=0.297). No significant difference was observed in terms of parity between two groups (p=0.206). Normal pregnant women were not significantly different from preeclampsia cases in the view of FT3 level (1.38 pg/ml vs. 1.41 pg/ml, p=0.803), FT4 level (0.95 pg/ml vs. 0.96 pg/ml, p=0.834) and TSH level (3.51 μIU/ml vs. 3.10 μIU/ml, p=0.386).Conclusion: The findings of the present study do not support the hypothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclampsia.
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Authors
Nayereh Khadem
Department of Obstetrics and Gynecology, Emam Reza Hospital, Women’s Health Research Center,Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein Ayatollahi
Department of Hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Fatemeh Vahid Roodsari
Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences,Mashhad, Iran.
Sedigheh Ayati
Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences,Mashhad, Iran.