Toxic effect of acyclovir on testicular tissue in rats
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-11-2_003
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Background: Acyclovir (ACV), a synthetic purine nucleoside analogue, is known to be toxic to gonads. Objective: The current study evaluated cytotoxicity of ACV on histopathologicalchanges in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats.Materials and Methods: Animals were divided into five groups. One group servedas control and one group served as control sham. In the drug treated groups ACVadministered for 15 days. 18 days after the last injection, animals were sacrificed. Histopathological and histomorphometrical analysis of the testis was carried out.Serum levels of testosterone and Lipid Peroxidation and potential fertility of animals was evaluated.Results: Male rats exposed to ACV had significant reduction in serum testosteroneconcentrations at 16 and 48mg/kg dose-levels (p<0.01). ACV induced histopathological changes in the testis and also increase the mean number of mast cells in peritubular or interstitial tissue in the testis at at 16 and 48mg/kg dose-levels(p<0.01). In addition ACV caused increase of serum level of Lipid Peroxidation at 48mg/kg dose-level (p<0.05). As well ACV decreased potential fertility in male rats.Conclusion: The present results highly support the idea that ACV has adverse effect on the reproductive system in male rat.
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Authors
Elham Movahed
Departmant of Biology, Faculty of Basic Sciences, Urmia University, Urmia, Iran
Vahid Nejati
Departmant of Biology, Faculty of Basic Sciences, Urmia University, Urmia, Iran
Rajabali Sadrkhanlou
Laboratory of Embryology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abbas Ahmadi
Laboratory of Embryology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran