Royal Jelly alleviates sperm toxicity and improves in vitro fertilization outcome in Stanozolol-treated mice
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-13-1_003
تاریخ نمایه سازی: 16 شهریور 1395
Abstract:
Background: Stanozolol (ST) is a synthetic anabolic-androgenic steroid often abused by athletes. An increasing body of evidence points towards the role of STmisuses in the pathogenesis of a wide range of adverse effects including reprotoxicity. Objective: The aim of this study was to analyze the possible reproprotective effectof royal jelly (RJ) as an efficient antioxidant in ST-treated mice. Materials and Methods: Adult male mice were divided into four groups (n=5).Two groups of mice received ST (4.6 mg/kg/day) via gavage for 35 days. RJ was given orally to one of these groups at the dose level of 100 mg/kg body weight perday synchronously. Untreated control group and RJ-only treated group were also included. Epididymal sperm characteristics and in vitro fertilizing capacity wereevaluated after 35 days. Results: ST treatment caused a significant (p<0.05) decrease in sperm count andmotility and fertilization rate along with poor blastocyst formation and increased sperm DNA damage. Moreover, the incidence of apoptosis and abnormality inspermatozoa was significantly (p<0.05) higher in ST-exposed mice than those of control. The above-mentioned parameters were restored to near normal level by RJco-administration. Conclusion: Data from the current study suggest that RJ has a potential reproprotectiveaction against ST-induced reproductive toxicity in mice. However, clinical studies are warranted to investigate such an effect in human subjects
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Authors
Ali Shalizar Jalali
Department of Basic Sciences,Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Gholamreza Najafi
Department of Basic Sciences,Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Mohammadreza Hosseinchi
Department of Basic Sciences,Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
Ashkan Sedighnia
Department of Basic Sciences,Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran