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Impact of the C1431T polymorphism of the PPAR-γ gene on susceptibility to obesity

Publish Year: 1395
Type: Conference paper
Language: English
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MPHBS01_059

Index date: 12 November 2016

Impact of the C1431T polymorphism of the PPAR-γ gene on susceptibility to obesity abstract

Introduction: The worldwide increasing prevalence of obesity is considered as a major health problem. The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with metabolic related disorder included obesity. However, the results have been inconsistent. Therefore, this cross-sectional study was conducted to explore the association between the PPARγ C1431T polymorphism and risk of obesity in an Iranian population. Materials and methods: TaqMan allelic discrimination assay was used to determine the C1431T polymorphisms in a total of 210 unrelated subjects, including 75/96 obese/overweight and 39 normal controls. Each group was then divided into two subgroups according to the genotype (CC and CT + TT for C1431T). Anthropometric indices, fasting plasma glucose and fasting lipid profile were measured by routine methods. Results: The genotype and allele frequencies of the C1431T exhibited no significant association with obesity neither in the crud state nor after adjustment for age and gender (P > 0.05). However, among the clinical and metabolic parameters tested, HDL-cholesterol showed higher level in individuals carrying the genotype CC (P=0.046). Conclusion: Our results indicated that despite the significant association of C1431T polymorphism with a higher HDL cholesterol level, the PPARγ gene does not appear to markedly play a role in the susceptibility to the development of obesity among Iranian subjects

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Impact of the C1431T polymorphism of the PPAR-γ gene on susceptibility to obesity authors

Hassan Mehrad Majd

Clinical Research Unit, Quaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Majid Ghayour Mobarhan

Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran