Anti-inflammatory effects of Tanacetum Balsamita essential oil on carageenan-induced Paw Edema in rats

Introduction: Tanacetum balsamita essential oil due to polyphenolic compounds that exist naturally in plants have analgesic and anti-inflammatory properties. Materials and methods: The anti-inflammatory property of Tanacetum balsamita essential oil (TBEO: 100, 150 and 250 mg/kg) assessed by carageenan-induced paw edema method in rats. Results: In carageenan test, dose of 250 mg/kg Tanacetum balsamita oil significantly reduced the paw edema in rats compared to animals that received vehicle only (p<0.05). The anti-inflammatory activity of Tanacetum balsamita essential oil was found to be more than standard drug, Mefenamic Acid (30mg/kg). The studied oil was analyzed by GC and GC–MS and forty four constituents, representing 84.1 % of the oil were identified. The major components of the oil were characterized as Carvone (39.8%) which might be responsible for this observed activity. Conclusion: The results suggest that Tanacetum Balsamita essential oil possesses biologically active constituents that have significant peripheral anti-inflammatory effects which support the ethnomedicinal claims of the plant application in the management of pain and inflammation.

Keywords:

Tanacetum Balsamita essential oil , Anti-inflammatory , Carageenan test , Rat