Electrochemical Determination of Anti Cancer Drug Imatinib, Using Nickel Nanopararticle Modifide Carbon Paste Electrode

Imatinib is one of the newest anticancer drugs in the market and was one of the first drugs to be pushed through Food and Drug Administration's (FDA) fast track designation for approval [1].Till now, the commonly employed techniques for the determination of this drug in bulk form, pharmaceutical formulation, and biological fluids are based on HPLC [2-4] and spectroscopy [1,5] methods .the problems encountered using such methods are need for time-consuming extraction procedures and expensive instrumentation so the use of simpler, faster, cheaper and also sensitive techniques can be interesting alternatives, especially those based onelectroanalytical techniques. Electrochemistry has many advantages, making it an appealingchoice for pharmaceutical analysis [6, 7] .The usefulness of modified carbonpaste electrodes (MCPEs) in the electroanalytical chemistry has been widely demonstrated and their development for analysis applications is still of great interest [8] .Nowadays, it is important to develop newmaterials capable to change the electrode surface with better analytical properties, includinggraphene, nanoparticles, and carbon nanotubes. Among them, nanosized metal particlemodified electrodes have emerged as a promising alternative for the electroanalysis of organic and inorganic compounds. [9, 10]. In this work for the first time, the electrocatalytic oxidation of Imatinib was carried out by nickelnanoparticles modified carbon paste electrode (Ni-NP/MCPE) using cyclic voltammetry and chronoamperometry methods. At first, nickel nanoparticles were synthesized by non-aqueouspolyol method and then these nanoparticles were mixed with graphite powder to form modified carbon paste electrode. Resulting modified electrode was characterized by SEM images. In the presence of 0.1 M NaOH a good redox behavior of the Ni(III)/Ni(II) couple at the surface ofelectrode can be observed. Imatinib was successfully oxidized at the surface of this modified electrode. The electrocatalytic oxidation peak current of this drug was linearly depending on itsconcentrations in range of 7×10-6 - 6×10-4 M. The proposed sensor exhibited a high sensitivity and was successfully applied for determination of Imatinib in some real samples

Keywords:

Electrocatalytic oxidation , Nickel nanoparticles , Non-aqueous polyol method , Imatinib