Synthesis of polypyrrole / TiO2-Fe2O3 nanocomposite and use it to identify drug fexofenadine hydrochloride

In This study the nanocomposite of PPy/TiO2_Fe2O3 is synthesized by chemical polymerization. The modified carbon paste electrode by the nanocomposite was used as an indicator electrode forthe determination of fexofenadine that is an antihistamine. The electrochemical behavior offexofenadine was studied by cyclic voltammetry on the electrode. The electrochemical behaviorof fexofenadine and effective factors such as pH, buffer, potential scan speed has been optimized. The results showed that the electrode has stability, high sensitivity and good electrochemical response to the fexofenadine in concentration ranges of 1.07*10-4-1.96*10-5 M in buffer solution of pH =7. The use of this nano-composite in the preparation of electrode improves thesensitivity and detection limit of the sensor and used successfully for determination of fexofenadine in real samples of pharmaceutical tablets.

Keywords:

nanocomposite , polypyrrole / TiO2 - Fe2O3 , nanosensor , conducting polymer