Fabrication of nanofibrs base on poly lactic acid for drug release in wound dressing

Biodegradable polymers are considered a suitable alternative to the improvement and development of numerous applications in medicine. Poly lactic acid (PLA) is an eco-friendly, biocompatible, processable and energy saving product with better features for use in the human body. In this study, poly lactic acid (PLA) nanofibers have been fabricated by electrospinning method. In the solvent system, choloroform (CHL) and dimethyl-formamide (DMF) gave high fiber productivity and fine defect free Nanofibers . Nanofiber morphology was observed by scanning electron microscopy (SEM). Then a Poly lactic acid (PLA) patch, has been prepared by loading antibiotics on poly lactic acid (PLA) nanofibers by solution method. Besides, Poly lactic acid has good biocompatibility, ease of surface chemistry modification and very high surface area, which may afford the possibility for their promising application in pharmacology and biomedical engineering areas

Keywords:

Poly lactic acid , Electrospinning , Nanofibers , Drug release , Biodegradable