Preparation of hydrogels by crosslinking starch through various diamines

Present study describes the synthesis and characterization of novel cross-linked hydrogels of carboxy methyl starch (CMS). The cross-linking of CMS with various diamines such as ethylene diamine (EDA), hexamethylene diamine (HMDA) and paraphenylene diamine (PPDA) were carried out in DMSO in the presence of dicyclohexyl carbodiimide (DCC) as activator and pyridine as condensing agent. The synthesized hydrogels were characterized using FT-IR. The loading of ceftizoxime antibiotic was carried out on CMS-HMDA and in vitro drug release behavior was investigated in three different media (HCl solution: pH=3 and buffer solutions: pH=6 and pH=8).

Keywords:

Carboxy methyl starch , Cross-linking , Diamine , Ceftizoxime , Drug release