Two novel methods for synthesizing poly (propylenefumarate): Technical aspects and role of vacuum and N2purging effects

Poly (propylene fumarate) (PPF), a linear unsaturated polyester consisting of alternating propylene glycol and fumaricacid units, can be cured in vivo to fll the skeletal defects with minimal surgical intervention. Many different methodshave been reported for synthesizing PPF, but none of them gives a clear method. The present paper introduces two newmethods in PPF synthesis: Modifed reflux system (MRS) and mixed reflux-distillation system (MRDS). Similarly,the effects of applying vacuum (vacuum sequence, time, vacuum applying position, and the distance between vacuumapplying position and reactor) as well as nitrogen gas (used continuously or only as an N2 blanket) on the PPF synthesishave been studied. The PPF obtained using optimum reaction condition has been characterized by using NMR, FTIR,and GPC analyses. It is demonstrated that the effciency of MRDS in synthesizing PPF is higher than that of MRS.Nitrogen gas, vacuum applying position, continuously/stepwise-continuously applying vacuum and other parametersshow an important role in the polymerization of PPF in both the MRDS and MRS systems. Polyolefns J (2017) 4:27-41

Two novel methods for synthesizing poly (propylenefumarate): Technical aspects and role of vacuum and N2purging effects Keywords:

Poly (propylene fumarate) , modifed reflux system , mixed reflux-distillation system